The Panthers fell to 18-25 overall and 9-11 in the CAA as the conference-leading Seahawks improved to 27-16 and 17-3 in the league.
GSU led 2-1 after three innings but struck out eight times against Seahawks left-hander Mat Batts (4-4).
Panther starter Ben Marshall (4-5) was knocked out after 4.2 innings, his shortest outing of the year, as UNCW tallied the deciding scores in a three-run fifth.
"We hit the ball well and got some things going but our hits weren't timely," said Panthers head coach Greg Frady. "We're not playing poorly but when you're playing a good team you need to have timely hits and two-out RBIs."
Kolowich and Caden Bailey led the attack with two hits apiece but the Panthers hit safely in just one of the game's final five innings.
UNCW tallied the first run of the game with a first-inning RBI single from Hunter Ridge.
Panthers loaded the bases in the third with a pair of singles and a walk. With two outs, Jonathan Kolowich legged out an infield single to score Landon Bennett and Brandon Williams came home on the play on a throwing error as GSU went up 2-1.
Corey Dick then belted his second homer of the series, a solo shot in the fourth, to tie the game at 2. Marshall ended a bases-loaded threat later in the inning by inducing a flyout.
The visitors pushed three more runs across against Marshall in the fifth to reclaim the lead, making it 5-2 on Michael Bass' RBI double.
A solo shot from Seahawks home run leader Tyler Molinaro in sixth made it 6-2.
After Greg Bowder doubled and moved to third in the bottom of the inning, Bailey scored him with an RBI single as GSU cut the deficit to 6-3.
The Seahawks added one run in the eighth however and the Panther bats went quiet against UNCW reliever Ricky Holden, who held GSU hitless over the final three innings to pick up his third save of the year.
The Panthers will try to salvage the final game of the series Sunday by hosting a 1 p.m. finale, which can be heard online from Voice of the Panthers Dave Cohen and WRAS.org, starting at 12:45 p.m.